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KMID : 0369820150450040349
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Jorunal of Korean Pharmaceutical Sciences
2015 Volume.45 No. 4 p.349 ~ p.358
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Development and optimization of sustained release polymeric microparticles by screening design
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Gawali Amol S.
Deshmukh Rameshwar K.
Naik Jitendra B.
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Abstract
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The aim of the present study was to investigate the effect of processing and formulation variables on polymeric microparticles, intended to be used for sustaining drug delivery of ibuprofen. Ibuprofen, polycaprolactone, dichloromethane (DCM), water, stirring speed and polyvinyl alcohol were selected as independent variables during the microparticles preparation. The independent variables influencing encapsulation efficiency (E.E.) and physical characteristics were assessed. The resultant microparticles were characterized for their E.E., surface morphology, and in vitro drug release. Ibuprofen loaded polymeric microparticles were characterized by FESEM, FTIR, DSC, and XRPD analysis. Graphical and mathematical analysis of the design showed that ibuprofen, polycaprolactone and DCM were significant effect on the E.E. of the microparticles. The low magnitudes of error and the significant values of R2 in the present investigation prove the high prognostic ability of the design. The microparticles showed high E.E. (76.11 ± 0.06?104.9 ± 0.46 %) with average particle size of 5?100 μm. The microparticles were found to be discrete, spherical with smooth surface. The FTIR analysis confirmed the compatibility of ibuprofen with the polymers. The XRPD and DSC study revealed the dispersion of drug within microparticles formulation. In vitro study showed sustain drug release over 12 h, thus prolong the drug action to treat the musculoskeletal disorder.
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KEYWORD
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Microparticles, Microencapsulation, Solvent evaporation method, Statistical experimental design
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